A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate
نویسندگان
چکیده
The catalyst-free multicomponent reaction of 1,2-diaminobenzene, dialkyl acetylenedicarboxylates, and ethyl bromopyruvate forms pyrrolo[1,2-a]quinoxaline derivatives in good yields. Ethylenediamine also reacts under similar conditions to produce new pyrrolo[1,2-a]pyrazine derivatives.
منابع مشابه
Green and efficient synthesis of trialkyl (E)-3-(3-Oxo-2-3,4-dihydro-2-(1H)-quinoxalinylidene)-prop-1-ene-1,2,3- tricarboxylates using K2CO3-PEG-400 as robust catalytic system
An efficient synthesis of trialkyl (E)-3-(3-Oxo-2-3,4-dihydro-2-(1H)-quinoxalinylidene)-prop-1-ene-1,2,3-tricarboxylate derivatives via a simple three-component reaction between benzene-1,2-diamines with dialkyl acetylenedicarboxylates in the presence of K2CO3-PEG catalytic system at 100 oC was reported. The desired products were obtained in excellent yields (88-92%). Various benzene-1,2-diamin...
متن کاملHantzsch reaction using [Mesi]Cl as a new, efficient and BAIL catalyst
In this work, the efficiency, generality and applicability of new Bronsted acidic ionic liquid (BAIL) 1-methyl-3-(2-(sulfooxy)ethyl)-1H-imidazol-3-ium chloride {[Msei]Cl} as heterogeneous and green catalyst for organic transformations are studied. Herein, the following one-pot multi-component reactions in the presence of [Msei]Cl are investigated: (i) the synthesis of quinoxaline derivatives fr...
متن کاملZnO nanoparticles as an Efficient and Reusable Catalyst for Synthesis of Quinoxaline under Solvent Free Condition
1,2-Diketones have been reacted in one-pot method with 1,2-diamines at room temperature with ZnO nanoparticles as a catalyst. ZnO nanoparticles as an available and reusable catalyst is used for the synthesis of Quinoxalinein improved yields.
متن کاملZnO nanoparticles as an Efficient and Reusable Catalyst for Synthesis of Quinoxaline under Solvent Free Condition
1,2-Diketones have been reacted in one-pot method with 1,2-diamines at room temperature with ZnO nanoparticles as a catalyst. ZnO nanoparticles as an available and reusable catalyst is used for the synthesis of Quinoxalinein improved yields.
متن کاملDicationic Ionic Liquid as the Recyclable Catalyst for the Synthesis of Quinoxaline Derivatives
An efficient and eco-friendly protocol for the synthesis of quinoxaline derivatives employing a condensation reaction between 1,2-diketone and 1,2-diaminobenzene derivative has been developed. The reaction of 1,2-diketone and 1,2-diaminobenzene derivative was carried out in water at room temperature using 10 mol% of task-specific dicationic ionic liquid as a catalyst. The results show that...
متن کامل